Publications
Senkowski, W., Gall-Mas, L., Falco, M. M., Li, Y., Lavikka, K., Kriegbaum, M. C., Oikkonen, J., Bulanova, D., Pietras, E. J., Voßgröne, K., Chen, Y. J., Erkan, E. P., Dai, J., Lundgren, A., Grønning Høg, M. K., Larsen, I. M., Lamminen, T., Kaipio, K., Huvila, J., ... Wennerberg, K. (2023). A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoids. Developmental Cell, 58(12), 1106-1121.e7. https://doi.org/10.1016/j.devcel.2023.04.012
The Irradiated Brain Microenvironment Supports Glioma Stemness and Survival via Astrocyte-Derived Transglutaminase 2.
Berg TJ, Marques C, Pantazopoulou V, Johansson E, von Stedingk K, Lindgren D, Jeannot P, Pietras EJ, Bergström T, Swartling FJ, Governa V, Bengzon J, Belting M, Axelson H, Squatrito M, Pietras A.Cancer Res. 2021 Apr 15;81(8):2101-2115. doi: 10.1158/0008-5472.CAN-20-1785. Epub 2021 Jan 22.PMID: 33483373
A high-throughput screen identifies the long non-coding RNA DRAIC as a regulator of autophagy. Tiessen I, Abildgaard MH, Lubas M, Gylling HM, Steinhauer C, Pietras EJ, Diederichs S, Frankel LB, Lund AH. Oncogene. 2019 Mar 14. doi: 10.1038/s41388-019-0783-9. [Epub ahead of print]
eIF5A is required for autophagy by mediating ATG3 translation. Lubas M, Harder LM, Kumsta C, Tiessen I, Hansen M, Andersen JS, Lund AH, Frankel LB. EMBO Rep. 2018 Jun;19(6). pii: e46072. doi: 10.15252/embr.201846072. Epub 2018 Apr 30.
Structure-Based Design of a New Scaffold for Cell-Penetrating Peptidic Inhibitors of the Histone Demethylase PHF8. Dorosz J, Olsen L, Seger ST, Steinhauer C, Bouras G, Helgstrand C, Wiuf A, Gajhede M. Chembiochem. 2017 Jul 18;18(14):1369-1375. doi: 10.1002/cbic.201700109. Epub 2017 Jun 13.
CD44 Interacts with HIF-2 to Modulate the Hypoxic Phenotype of Perinecrotic and Perivascular Glioma Cells. Johansson, Elinn; Grassi, Elisa S.; Pantazopoulou, Vasiliki; Tong, Bei; Lindgren, David; Berg, Tracy J.; Pietras, Elin Josefina; Axelson, Håkan; Pietras, Alexander. Cell Reports. 15 August 2017 Volume 20, Issue 7, Pages 1641-1653
https://doi.org/10.1016/j.celrep.2017.07.049
High-throughput siRNA screening applied to the ubiquitin-proteasome system. Poulsen EG, Nielsen SV, Pietras EJ, Johansen JV, Steinhauer C and Hartmann-Petersen R Methods in Molecular Biology: Proteostasis 2016; 1449:421-39
Cyclin F suppresses B-Myb activity to promote cell cycle checkpoint control. Klein DK, Hoffmann S, Ahlskog JK, O'Hanlon K, Quaas M, Larsen BD, Rolland B, Rösner HI, Walter D, Kousholt AN, Menzel T, Lees M, Johansen JV, Rappsilber J, Engeland K, Sørensen CS. Nat Commun. 2015 Jan 5;6:5800. doi: 10.1038/ncomms6800.
miR-339-5p regulates the p53 tumor-suppressor pathway by targeting MDM2. Jansson MD, Damas ND, Lees M, Jacobsen A, Lund AH.Oncogene. 2014 Jun 2. doi: 10.1038/onc.2014.130. [Epub ahead of print]
New histone supply regulates replication fork speed and PCNA unloading. Mejlvang J, Feng Y, Alabert C, Neelsen KJ, Jasencakova Z, Zhao X, Lees M, Sandelin A, Pasero P, Lopes M, Groth A. J Cell Biol. 2014 Jan 6;204(1):29-43. doi: 10.1083/jcb.201305017. Epub 2013 Dec 30.
A Screen Identifies the Oncogenic Micro-RNA miR-378a-5p as a Negative Regulator of Oncogene-Induced Senescence. Kooistra SM, Nørgaard LC, Lees MJ, Steinhauer C, Johansen JV, Helin K. PLoS One. 2014 Mar 20;9(3):e91034. doi: 10.1371/journal.pone.0091034. eCollection 2014.
Histone acetyltransferase PCAF is required for Hedgehog-Gli-dependent transcription and cancer cell proliferation. Malatesta M, Steinhauer C, Mohammad F, Pandey DP, Squartrito M, Helin K. (2013) Cancer Res. 2013 Aug 13. [Epub ahead of print]
A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation. Ambjørn M, Dubreuil V, Miozzo F, Nigon F, Møller B, Issazadeh-Navikas S, Berg J, Lees M, Sap J. (2013). PLoS One. 2013 Jun 13;8(6):e65371. doi: 10.1371/journal.pone.0065371. Print 2013.
IFNB1/interferon-β-induced autophagy in MCF-7 breast cancer cells counteracts its proapoptotic function. Ambjørn M, Ejlerskov P, Liu Y, Lees M, Jäättelä M, Issazadeh-Navikas S. Autophagy. 2012 Dec 7;9(3).
HUWE1 and TRIP12 Collaborate in Degradation of Ubiquitin-Fusion Proteins and Misframed Ubiquitin. Poulsen EG, Steinhauer C, Lees M, Lauridsen AM, Ellgaard L, Hartmann-Petersen R. PLoS One. 2012;7(11):e50548. doi: 10.1371/journal.pone.0050548. Epub 2012 Nov 27.
Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor. Kristensen LH, Nielsen AL, Helgstrand C, Lees M, Cloos P, Kastrup JS, Helin K, Olsen L, Gajhede M. FEBS J. 2012 Jun;279(11):1905-14. doi: 10.1111/j.1742-4658.2012.08567.x. Epub 2012 May 2.
Identification of catechols as histone-lysine demethylase inhibitors. Nielsen AL, Kristensen LH, Stephansen KB, Kristensen JB, Helgstrand C, Lees M, Cloos P, Helin K, Gajhede M, Olsen L. FEBS Lett. 2012 Apr 24;586(8):1190-4. Epub 2012 Mar 15.
microRNA-101 is a potent inhibitor of autophagy. Frankel LB, Wen J, Lees M, Høyer-Hansen M, Farkas T, Krogh A, Jäättelä M, Lund AH. EMBO J. 2011 Sep 13. doi: 10.1038/emboj.2011.331 .
A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance. Menzel T, Nähse-Kumpf V, Kousholt AN, Klein DK, Lund-Andersen C, Lees M, Johansen JV, Syljuåsen RG, Sørensen CS. EMBO Rep. 2011 Jul 1;12(7):705-12. doi: 10.1038/embor.2011.99.
Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase. Beck H, Nähse V, Larsen MS, Groth P, Clancy T, Lees M, Jørgensen M, Helleday T, Syljuåsen RG, Sørensen CS. J Cell Biol. 2010 Mar 8;188(5):629-38. Epub 2010 Mar 1.
p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC. Christoffersen NR, Shalgi R, Frankel LB, Leucci E, Lees M, Klausen M, Pilpel Y, Nielsen FC, Oren M, and A. H. Lund. (2010). Cell Death and Differentiation 17:236-45.